Article
Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability.
Arthritis and rheumatism - 1 Sept 2009
Dhaenens Maarten, Fert Ingrid, Glatigny Simon, Haerinck Saskia, Poulain Cécile, Donnadieu Emmanuel, Hacquard-Bouder Cécile, André Claudine, Elewaut Dirk, Deforce Dieter, Breban Maxime
Abstract excerpt
OBJECTIVE: Spondylarthritis (SpA) is characterized by spinal and peripheral joint inflammation, frequently combined with extraarticular manifestations. Despite the well-established association of SpA with the class I major histocompatibility complex (MHC) allele HLA-B27, there are still different, parallel hypotheses on the relationship between HLA-B27 and disease mechanisms. The present study was undertaken to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.