Gene conversion in steroid 21-hydroxylase genes.

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Article

Gene conversion in steroid 21-hydroxylase genes.

American journal of human genetics - 1 Jun 1990

Urabe K, Kimura A, Harada F, Iwanaga T, Sasazuki T

Abstract excerpt

The steroid 21-hydroxylase gene, CYP21B, encodes cytochrome P450c21, which mediates 21-hydroxylation. The gene is located about 30 kb downstream from pseudogene CYP21A. The CYP21A gene is homologous to the CYP21B gene but contains some mutations, including a C----T change which leads a termination codon, TAG, in the eighth exon. We found the same change in a mutant CYP21B gene isolated from a patient with...

Topics

Adrenal Hyperplasia, Congenital
Base Sequence
Blotting, Southern
Chromosome Mapping
Female
Gene Conversion
Genes
HLA-B Antigens
HLA-B44 Antigen
Haplotypes
Humans
Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Polymorphism, Restriction Fragment Length

Steroid 21-Hydroxylase

Steroid Hydroxylases

Source

Open in PubMed Open full text

Identifiers

PMID: 1971153
PMCID: PMC1683832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1971153-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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