Article
Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences.
BMC genetics - 25 Aug 2009
Fontanesi Luca, Beretti Francesca, Riggio Valentina, Dall'Olio Stefania, González Elena Gómez, Finocchiaro Raffaella, Davoli Roberta, Russo Vincenzo, Portolano Baldassare
Abstract excerpt
BACKGROUND: Agouti and Extension loci control the relative amount of eumelanin and pheomelanin production in melanocytes that, in turn, affects pigmentation of skin and hair. The Extension locus encodes the melanocortin 1 receptor (MC1R) whose permanent activation, caused by functional mutations, results in black coat colour, whereas other inactivating mutations cause red coat colour in different mammals....
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