Article
Plasticity of human mesenchymal stem cell phenotype and expression profile under neurogenic conditions.
Bulletin of experimental biology and medicine - 1 Apr 2009
Shakhbazau A V, Shakhbazov A V, Goncharova N V, Kosmacheva S M, Kartel' N A, Potapnev M P
Abstract excerpt
Human bone marrow MSC cultured in neurogenic medium containing EGF and FGFbeta demonstrated alteration of the phenotype and expression of neuronal precursor/early neuron markers nestin and NSE. Signals of expression of neuronal and oligodendroglial markers MAP-2, dm-20, and MBP were detected after prolongation of incubation in neurogenic medium to 2 weeks. Cells with neuronal morphology were immunopositive to...
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