Article
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.
Nature genetics - 1 Sept 2009
Dendrou Calliope A, Plagnol Vincent, Fung Erik, Yang Jennie H M, Downes Kate, Cooper Jason D, Nutland Sarah, Coleman Gillian, Himsworth Matthew, Hardy Matthew, Burren Oliver, Healy Barry, Walker Neil M, Koch Kerstin, Ouwehand Willem H, Bradley John R, Wareham Nicholas J, Todd John A, Wicker Linda S
Abstract excerpt
Genome-wide association studies (GWAS) have identified over 300 regions associated with more than 70 common diseases. However, identifying causal genes within an associated region remains a major challenge. One approach to resolving causal genes is through the dissection of gene-phenotype correla...
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