Antiretroviral treatment outcome following genotyping in Thai children who failed dual nucleoside reverse transcriptase inhibitors.

doi:10.1016/j.ijid.2009.05.017

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Article

Antiretroviral treatment outcome following genotyping in Thai children who failed dual nucleoside reverse transcriptase inhibitors.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2010

Bunupuradah Torsak, Suntarattiwong Piyarat, Li Andrea, Sirivichayakul Sunee, Pancharoen Chitsanu, Boonrak Pitch, Puthanakit Thanyawee, Kerr Stephen J, Ruxrungtham Kiat, Chotpitayasunondh Tawee, Hirschel Bernard, Ananworanich Jintanat

Abstract excerpt

OBJECTIVE: To evaluate outcomes in dual nucleoside reverse transcriptase inhibitor (NRTI) pretreated children after genotyping (GT). METHODS: We assessed CD4 and viral load (VL) in children three years after baseline GT at the time of dual NRTI failure. Baseline high grade resistance (HR) was defined as >or=4 nucleoside analogue mutations (NAMs)+/-Q151M or 69 insertion complex, and low grade resistance (LR) was...

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PMID: 19699673
DOI: 10.1016/j.ijid.2009.05.017

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