Article
Resistance to dual nucleoside reverse-transcriptase inhibitors in children infected with HIV clade A/E.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jan 2005
Lolekha Rangsima, Sirivichayakul Sunee, Siangphoe Umaporn, Pancharoen Chitsanu, Kaewchana Suchada, Apateerapong Wichitra, Mahanontharit Apicha, Chotpitayasunondh Tawee, Ruxrungtham Kiat, Phanuphak Praphan, Ananworanich Jintanat
Abstract excerpt
The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.
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