Article
Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model.
Journal of epidemiology and community health - 1 Jun 2010
Lucena-Silva N, Baliza M D, Martins A E S, Deghaide N H S, Teixeira K M, Rodrigues L C, Ximenes R, Donadi E A, de Albuquerque M d F P M
Abstract excerpt
BACKGROUND: Tuberculosis clusters in families may be due to increased household exposure, shared genetic factors, or both. Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contribution of relatedness to disease development. METHODS: In this study, the familial aggregation of tuberculosis using...
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