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Article

Heredity versus environment in tuberculosis in twins: the 1950s United Kingdom Prophit Survey Simonds and Comstock revisited.

American journal of respiratory and critical care medicine - 15 Dec 2007

van der Eijk Ellen A, van de Vosse Esther, Vandenbroucke Jan P, van Dissel Jaap T

Abstract excerpt

RATIONALE: In his 1978 article on tuberculosis (TB) in twins, Comstock concluded that the 2.5-fold higher concordance rate for TB among monozygotic versus dizygotic twins in the Prophit survey of the 1950s implicated inherited susceptibility as a major risk factor for TB in humans. His analysis did not take into account strong imbalance of variables within subgroups, underestimating possible confounding effects...

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Identifiers

PMID: 17823356
DOI: 10.1164/rccm.200703-435OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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