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Article

Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.

Cancer science - 1 Nov 2009

Ohta Kazutaka, Kuwahara Kazuhiko, Zhang Zhenhuan, Makino Keishi, Komohara Yoshihiro, Nakamura Hideo, Kuratsu Jun-ichi, Sakaguchi Nobuo

Abstract excerpt

Malignant glioma (MG) is highly proliferative and invasive, with the malignant characteristics associated with aneuploidy and chromosomal instability (CIN). Here, we found that the level of germinal center-associated nuclear protein (GANP), a mammalian homologue of yeast Sac3, was markedly decreased in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell...

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Identifiers

PMID: 19686285
DOI: 10.1111/j.1349-7006.2009.01293.x
PMCID: PMC11158849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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