Article
Discordant somatic and germline VEGF-A genotype in a cancer patient resistant to paclitaxel/bevacizumab with chemosensitive hepatic metastasis.
Pharmacogenomics - 1 Aug 2009
Coltelli Luigi, Allegrini Giacomo, Orlandi Paola, Giuntini Nicola, Alì Greta, Fioravanti Anna, Bona Eleonora, Barletta Maria Teresa, Fontanini Gabriella, Del Tacca Mario, Danesi Romano, Falcone Alfredo, Bocci Guido
Abstract excerpt
Recent data reported an association between VEGF-A genotype of tumors and median overall survival as well as grade 3 or 4 hypertension when using bevacizumab in metastatic breast cancer. In the present case we report a discordant VEGF-A genotype between tumor and normal tissue in a patient with a responsive hepatic lesion of chemoresistant breast cancer treated with bevacizumab and paclitaxel. Moreover, we show...
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