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Article

Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells.

Journal of neurochemistry - 1 Oct 2009

Kim Yeni, Lee Yun-Il, Seo Miran, Kim So-Young, Lee Ji-Eun, Youn Hong-Duk, Kim Yong-Sik, Juhnn Yong-Sung

Abstract excerpt

This study examined the role of calcineurin, a major calcium-dependent protein phosphatase, in dephosphorylating Ser-9 and activating glycogen synthase kinase-3beta (GSK-3beta). Treatment with calcineurin inhibitors increased phosphorylation of GSK-3beta at Ser-9 in SH-SY5Y human neuroblastoma cells. The over-expression of a constitutively active calcineurin mutant, calcineurin A beta (1-401), led to a...

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Identifiers

PMID: 19659461
DOI: 10.1111/j.1471-4159.2009.06318.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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