Article
Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.
Circulation - 18 Aug 2009
Milan David J, Kim Albert M, Winterfield Jeffrey R, Jones Ian L, Pfeufer Arne, Sanna Serena, Arking Dan E, Amsterdam Adam H, Sabeh Khaled M, Mably John D, Rosenbaum David S, Peterson Randall T, Chakravarti Aravinda, Kääb Stefan, Roden Dan M, MacRae Calum A
Abstract excerpt
BACKGROUND: Cardiac repolarization, the process by which cardiomyocytes return to their resting potential after each beat, is a highly regulated process that is critical for heart rhythm stability. Perturbations of cardiac repolarization increase the risk for life-threatening arrhythmias and sudden cardiac death. Although genetic studies of familial long-QT syndromes have uncovered several key genes in cardiac...
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