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Article

AIRE deficiency leads to impaired iNKT cell development.

Journal of autoimmunity - 1 Feb 2010

Lindh Emma, Rosmaraki Eleftheria, Berg Louise, Brauner Hanna, Karlsson Mikael C I, Peltonen Leena, Höglund Petter, Winqvist Ola

Abstract excerpt

Autoimmune Polyendocrine Syndrome type I (APS I) is caused by mutations in the Autoimmune Regulator gene (AIRE), and results in the immunological destruction of endocrine organs. Herein we have characterized the CD1d-restricted invariant NKT cells (iNKT) and NK cells in APS I patients and Aire(-/-) mice, two cell populations known to play a role in the regulation of autoimmune disease. We show that the frequency...

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Source

Identifiers

PMID: 19651488
DOI: 10.1016/j.jaut.2009.07.002

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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