Article
A minimal model for hepatic fatty acid balance during fasting: application to PPAR alpha-deficient mice.
Journal of theoretical biology - 21 Nov 2009
Blavy P, Gondret F, Guillou H, Lagarrigue S, Martin P G P, van Milgen J, Radulescu O, Siegel A
Abstract excerpt
The purpose of this study is to identify the hierarchy of importance amongst pathways involved in fatty acid (FA) metabolism and their regulators in the control of hepatic FA composition. A modeling approach was applied to experimental data obtained during fasting in PPARalpha knockout (KO) mice and wild-type mice. A step-by-step procedure was used in which a very simple model was completed by additional pathways...
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