Article
Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients.
Cytotherapy - 1 Jan 2009
Coipeau Patrick, Rosset Philippe, Langonne Alain, Gaillard Julien, Delorme Bruno, Rico Angélique, Domenech Jorge, Charbord Pierre, Sensebe Luc
Abstract excerpt
BACKGROUND AIMS: Advances in bone tissue engineering with mesenchymal stromal cells (MSC) as an alternative to conventional orthopedic procedures has opened new horizons for the treatment of large bone defects. Bone marrow (BM) and trabecular bone are both sources of MSC. Regarding clinical use, we tested the potency of MSC from different sources. METHODS: We obtained MSC from 17 donors (mean age 64.6 years) by...
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