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Article

Pilocytic astrocytoma in a child with Noonan syndrome.

Pediatric blood & cancer - 1 Dec 2009

Schuettpelz Laura G, McDonald Sharon, Whitesell Kristina, Desruisseau David M, Grange Dorothy K, Gurnett Christina A, Wilson David B

Abstract excerpt

Noonan syndrome (NS; MIM 163950) is an autosomal dominant dysmorphic syndrome characterized by distinct facial features, cardiac anomalies, short stature, and motor delay. Activating mutations in PTPN11, encoding the protein tyrosine phosphatase SHP2, are associated with about 50% of cases. Mutations in other genes in the RAS/mitogen-activated protein kinase signaling pathway are responsible for many of the...

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Source

Identifiers

PMID: 19621452
DOI: 10.1002/pbc.22193

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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