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Article

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009

Nakajima Akira, Nishimura Keishiro, Nakaima Yukana, Oh Tomohiko, Noguchi Shigeru, Taniguchi Tadatsugu, Tamura Tomohiko

Abstract excerpt

The generation of mice lacking the expression of the IRF3 transcription factor (Irf3(-/-) mice) has revealed its crucial role in the activation of the type I IFN response. The Bcl2l12 gene, encoding Bcl2L12 protein structurally related to the Bcl-2 family, was found to almost overlap with the Irf...

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Identifiers

PMID: 19617565
DOI: 10.1073/pnas.0905702106
PMCID: PMC2718395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19617565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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