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Article

Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency.

Biochimica et biophysica acta - 1 Mar 2010

Komaki Hirofumi, Nishigaki Yutaka, Fuku Noriyuki, Hosoya Hiroko, Murayama Kei, Ohtake Akira, Goto Yu-Ichi, Wakamoto Hiroyuki, Koga Yasutoshi, Tanaka Masashi

Abstract excerpt

BACKGROUND: Recently we proposed the therapeutic potential of pyruvate therapy for mitochondrial diseases. Leigh syndrome is a progressive neurodegenerative disorder ascribed to either mitochondrial or nuclear DNA mutations. METHODS: In an attempt to circumvent the mitochondrial dysfunction, we orally applied sodium pyruvate and analyzed its effect on an 11-year-old female with Leigh syndrome due to cytochrome c...

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Identifiers

PMID: 19616603
DOI: 10.1016/j.bbagen.2009.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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