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Article

Conditional antisense-knockdown of zebrafish cardiac troponin C as a new animal model for dilated cardiomyopathy.

Circulation journal : official journal of the Japanese Circulation Society - 1 Sept 2009

Ho Yi-Lwun, Lin Yen-Hung, Tsai Wei-Yuan, Hsieh Fong-Jou, Tsai Huai-Jen

Abstract excerpt

BACKGROUND: Mutations of cardiac troponin C (cTnC) can cause dilated cardiomyopathy in humans. METHODS AND RESULTS: Plasmids were constructed such that the reverse tetracycline-controlled transactivator (rtTA) was driven by the cardiac myosin light chain 2 promoter. This heart-specific rtTA bound another bidirectional promoter to express the green fluorescence protein reporter gene and the antisense RNA of cTnC...

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Source

Identifiers

PMID: 19609041
DOI: 10.1253/circj.cj-09-0210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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