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Article

Reversal of RNA Dominance by Displacement of Protein Sequestered on Triplet Repeat RNA

16 Jul 2009

Abstract excerpt

Genomic expansions of simple tandem repeats can give rise to toxic RNAs that contain expanded repeats. In myotonic dystrophy, the expression of expanded CUG repeats (CUGexp) causes abnormal regulation of alternative splicing and neuromuscular dysfunction. We used a transgenic mouse model to show that derangements of myotonic dystrophy are reversed by a morpholino antisense oligonucleotide, CAG25, that binds to...

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PMID: 19608921
DOI: 10.1126/science.1173110

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