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Article

Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803.

Biotechnology progress - 1 Jan 2000

Tyo Keith E J, Jin Yong-Su, Espinoza Freddy A, Stephanopoulos Gregory

Abstract excerpt

Inverse metabolic engineering (IME) is a combinatorial approach for identifying genotypes associated with a particular phenotype of interest. In this study, gene disruptions that increase the biosynthesis of poly-3-hydroxybutyrate (PHB) in the photosynthetic bacterium Synechocystis PCC6803 were identified. A Synechocystis mutant library was constructed by homologous recombination between the Synechocystis genome...

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PMID: 19606467
DOI: 10.1002/btpr.228

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