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Dating the emergence of pandemic influenza viruses

13 Jul 2009

Abstract excerpt

Pandemic influenza viruses cause significant mortality in humans. In the 20th century, 3 influenza viruses caused major pandemics: the 1918 H1N1 virus, the 1957 H2N2 virus, and the 1968 H3N2 virus. These pandemics were initiated by the introduction and successful adaptation of a novel hemagglutinin subtype to humans from an animal source, resulting in antigenic shift. Despite global concern regarding a new...

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PMID: 19597152
DOI: 10.1073/pnas.0904991106

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