Article
Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: a meta-analysis.
JAMA - 9 Apr 2014
Lee June-Koo, Hahn Seokyung, Kim Dong-Wan, Suh Koung Jin, Keam Bhumsuk, Kim Tae Min, Lee Se-Hoon, Heo Dae Seog
Abstract excerpt
IMPORTANCE: Current guidelines recommend both epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and cytotoxic chemotherapy drugs as standard treatment options for patients with wild-type (WT) EGFR who were previously treated for non-small cell lung cancer (NSCLC). However, it is not clear that EGFR TKIs are as efficacious as chemotherapy in patients with WT EGFR. OBJECTIVE: To determine...
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