Article
Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
PloS one - 13 Jul 2009
Banks Gareth T, Bros-Facer Virginie, Williams Hazel P, Chia Ruth, Achilli Francesca, Bryson J Barney, Greensmith Linda, Fisher Elizabeth M C
Abstract excerpt
BACKGROUND: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal muscular atrophy. GARS is ubiquitously expressed and may have functions in addition to its canonical role in protein synthesis through catalyzing the addition of...
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