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Article

Dimerization is required for GARS-mediated neurotoxicity in dominant CMT disease.

Human molecular genetics - 15 Apr 2016

Malissovas Nikos, Griffin Laurie B, Antonellis Anthony, Beis Dimitris

Abstract excerpt

Charcot-Marie-Tooth (CMT) disease is a genetically heterogeneous group of peripheral neuropathies. Mutations in several aminoacyl-tRNA synthetase (ARS) genes have been implicated in inherited CMT disease. There are 12 reported CMT-causing mutations dispersed throughout the primary sequence of the human glycyl-tRNA synthetase (GARS). While there is strong genetic evidence linking GARS mutations to CMT disease, the...

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Identifiers

PMID: 27008886
DOI: 10.1093/hmg/ddw031
PMCID: PMC4805310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dimerization is required for GARS-mediated neurotoxicity in dominant CMT disease.PMID 27008886Read ↗

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