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Article

GARS axonopathy: not every neuron's cup of tRNA.

Trends in neurosciences - 1 Feb 2010

Motley William W, Talbot Kevin, Fischbeck Kenneth H

Abstract excerpt

Charcot-Marie-Tooth disease type 2D, a hereditary axonal neuropathy, is caused by mutations in glycyl-tRNA synthetase (GARS). The mutations are distributed throughout the protein in multiple functional domains. In biochemical and cell culture experiments, some mutant forms of GARS have been indistinguishable from wild-type protein, suggesting that these in vitro tests might not adequately assess the aberrant...

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Identifiers

PMID: 20152552
DOI: 10.1016/j.tins.2009.11.001
PMCID: PMC2822721

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