Iron differentially regulates gene expression and extracellular secretion of Vibrio vulnificus cytolysin-hemolysin.

Abstract excerpt

In a previous study, we showed that Vibrio vulnificus is a ferrophilic bacterium that requires high levels of available iron for growth. In the present study, we show that iron stimulates, in an unusual manner, the production of cytolysin-hemolysin (VvhA), the most potent exotoxin produced by V. vulnificus. The vvhA gene possesses a putative ferric uptake regulator (Fur)-binding box in the regulatory region,...

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