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Article

A new isolation with migration model along complete genomes infers very different divergence processes among closely related great ape species.

PLoS genetics - 1 Jan 2012

Mailund Thomas, Halager Anders E, Westergaard Michael, Dutheil Julien Y, Munch Kasper, Andersen Lars N, Lunter Gerton, Prüfer Kay, Scally Aylwyn, Hobolth Asger, Schierup Mikkel H

Abstract excerpt

We present a hidden Markov model (HMM) for inferring gradual isolation between two populations during speciation, modelled as a time interval with restricted gene flow. The HMM describes the history of adjacent nucleotides in two genomic sequences, such that the nucleotides can be separated by recombination, can migrate between populations, or can coalesce at variable time points, all dependent on the parameters...

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PMID: 23284294
DOI: 10.1371/journal.pgen.1003125
PMCID: PMC3527290

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