Article
Cowpea mosaic virus nanoscaffold as signal enhancement for DNA microarrays.
Biosensors & bioelectronics - 15 Sept 2009
Soto Carissa M, Blaney Kate M, Dar Mubasher, Khan Manzer, Lin Baochuan, Malanoski Anthony P, Tidd Cherise, Rios Mayrim V, Lopez Darlah M, Ratna Banahalli R
Abstract excerpt
Previous studies have shown that a functionalized viral nanoparticle can be used as a fluorescent signal-generating element and enhance detection sensitivity for immunoassays and low density microarrays. In this study, we further tested this ability in commercial DNA microarrays, including Affymetrix high density resequencing microarray. Optimum conditions for NeutrAvidin and dye coupling to a double-cysteine...
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