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Article

The Transcriptional Response of the Islet to Pregnancy in Mice

2 Jul 2009

Abstract excerpt

The inability of the ss-cell to meet the demand for insulin brought about by insulin resistance leads to type 2 diabetes. In adults, ss-cell replication is one of the mechanisms thought to cause the expansion of ss-cell mass. Efforts to treat diabetes require knowledge of the pathways that drive facultative ss-cell proliferation in vivo. A robust physiological stimulus of ss-cell expansion is pregnancy and...

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Identifiers

PMID: 19574445
DOI: 10.1210/me.2009-0144

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