Article
Germline mutations in CDKN2A are infrequent in female patients with melanoma and breast cancer.
Melanoma research - 1 Aug 2009
Nagore Eduardo, Montoro Alegria, García-Casado Zaida, Botella-Estrada Rafael, Insa Amelia, Lluch Ana, López-Guerrero José A, Guillén Carlos
Abstract excerpt
Carriers of mutations in the melanoma susceptibility gene, CDKN2A, exhibit a higher than expected risk of breast cancer. In this study, we aimed to determine mutations in the CDKN2A gene in patients with melanoma and additional breast cancer. Thirty-one women with histologically confirmed melanoma and breast cancer were studied for CDKN2A/ARF gene mutations by direct sequencing analysis. We identified four CDKN2A...
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