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Article

The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.

Development (Cambridge, England) - 1 Aug 2009

Dodd M Ernest, Hatzold Julia, Mathias Jonathan R, Walters Kevin B, Bennin David A, Rhodes Jennifer, Kanki John P, Look A Thomas, Hammerschmidt Matthias, Huttenlocher Anna

Abstract excerpt

Epidermal hyperproliferation and inflammation are hallmarks of the human condition psoriasis. Here, we report that a zebrafish line with a mutation in the cargo adaptor protein Clint1 exhibits psoriasis-like phenotypes including epithelial hyperproliferation and leukocyte infiltration. Clint1 is an ENTH domain-containing protein that binds SNARE proteins and functions in vesicle trafficking; however, its in vivo...

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Identifiers

PMID: 19570844
DOI: 10.1242/dev.038448
PMCID: PMC2709065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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