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Article

Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis.

Disease models & mechanisms - 1 Nov 2011

Li Qiaoli, Frank Michael, Akiyama Masashi, Shimizu Hiroshi, Ho Shiu-Ying, Thisse Christine, Thisse Bernard, Sprecher Eli, Uitto Jouni

Abstract excerpt

Zebrafish (Danio rerio) can serve as a model system to study heritable skin diseases. The skin is rapidly developed during the first 5-6 days of embryonic growth, accompanied by expression of skin-specific genes. Transmission electron microscopy (TEM) of wild-type zebrafish at day 5 reveals a two-cell-layer epidermis separated from the underlying collagenous stroma by a basement membrane with fully developed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21816950
DOI: 10.1242/dmm.007146
PMCID: PMC3209647

Genes

ABCA12
SNAP29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis.PMID 21816950Read ↗

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ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.Semantic proximity Read ↗

A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid HomeostasisSemantic proximity Read ↗

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Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defectsSemantic proximity Read ↗

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Heterogeneity in Harlequin Ichthyosis, an Inborn Error of Epidermal Keratinization: Variable Morphology and Structural Protein Expression and a Defect in Lamellar GranulesSemantic proximity Read ↗

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