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DNA methylation and histone modification regulate silencing of OPG during tumor progression

29 Jun 2009

Abstract excerpt

The identification of molecules that are down-regulated in malignant phenotype is important for understanding tumor biology and their role in tumor suppression. We compared the expression profile of four normal nasal mucosal (NNM) epithelia and a series of nasopharyngeal cancinoma (NPC) cell lines using cDNA microarray and confirmed the actual expression of the selected genes, and found osteoprotegerin (OPG) to...

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PMID: 19565568
DOI: 10.1002/jcb.22256

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