Article
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell.
RNA (New York, N.Y.) - 1 Aug 2009
Sotiropoulou Georgia, Pampalakis Georgios, Lianidou Evi, Mourelatos Zissimos
Abstract excerpt
Transformation of normal cells into malignant tumors requires the acquisition of six hallmark traits, e.g., self-sufficiency in growth signals, insensitivity to antigrowth signals and self-renewal, evasion of apoptosis, limitless replication potential, angiogenesis, invasion, and metastasis, which are common to all cancers (Hanahan and Weinberg 2000). These new cellular traits evolve from defects in major...
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