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Article

Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

Biochemical and biophysical research communications - 4 Sept 2009

Mitsiki Eirini, Papageorgiou Anastassios C, Iyer Shalini, Thiyagarajan Nethaji, Prior Steven H, Sleep Darrell, Finnis Chris, Acharya K Ravi

Abstract excerpt

Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we report the crystal structures of recombinant hTP and its complex with a substrate 5-iodouracil (5IUR) at 3.0 and 2.5A, respectively. In addition, we provide...

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Identifiers

PMID: 19555658
DOI: 10.1016/j.bbrc.2009.06.104
PMCID: PMC2719695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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