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Review: Autophagy in neurodegeneration: firefighter and/or incendiarist?

25 Jun 2009

Abstract excerpt

Autophagy is an intracellular bulk degradation system that is found ubiquitously in eukaryotes. Autophagy is responsible for the degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membrane autophagosomes, which subsequently fuse with lysosomes where their contents are degraded. This system has been implicated in various...

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PMID: 19555462
DOI: 10.1111/j.1365-2990.2009.01034.x

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