Article
Two commonly occurring nucleotide base substitutions in Chinese G6PD variants.
Biochemical and biophysical research communications - 31 Oct 1991
Chiu D T, Zuo L, Chen E, Chao L, Louie E, Lubin B, Liu T Z, Du C S
Abstract excerpt
Using a direct PCR sequencing technique, we have identified two DNA base substitutions in 8 different biochemical G6PD variants of Chinese origin. Neither one of these abnormalities has been reported in other ethnic groups. An abnormality (C1) of G to T substitution at cDNA 1376 causing an amino acid change from Arg to Leu has been found in 3 variants. Another abnormality (C2) of G to A substitution at cDNA 1388...
Topics
- Base Sequence
- China
- Exons
- Genetic Variation
- Glucosephosphate Dehydrogenase
- Glucosephosphate Dehydrogenase Deficiency
- Kinetics
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction