Article
A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.
The EMBO journal - 8 Jul 2009
Mao Yuxin, Balkin Daniel M, Zoncu Roberto, Erdmann Kai S, Tomasini Livia, Hu Fenghua, Jin Moonsoo M, Hodsdon Michael E, De Camilli Pietro
Abstract excerpt
OCRL, whose mutations are responsible for Lowe syndrome and Dent disease, and INPP5B are two similar proteins comprising a central inositol 5-phosphatase domain followed by an ASH and a RhoGAP-like domain. Their divergent NH2-terminal portions remain uncharacterized. We show that the NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain. OCRL, which in contrast to INPP5B visits late stage...
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