Article
Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy.
Neurotoxicity research - 1 Jul 2009
Capone Ricardo, Quiroz Felipe Garcia, Prangkio Panchika, Saluja Inderjeet, Sauer Anna M, Bautista Mahealani R, Turner Raymond S, Yang Jerry, Mayer Michael
Abstract excerpt
Understanding the pathogenicity of amyloid-beta (Abeta) peptides constitutes a major goal in research on Alzheimer's disease (AD). One hypothesis entails that Abeta peptides induce uncontrolled, neurotoxic ion flux through cellular membranes. The exact biophysical mechanism of this ion flux is, however, a subject of an ongoing controversy which has attenuated progress toward understanding the importance of...
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