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Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis

12 Jun 2009

Abstract excerpt

BACKGROUND: Whereas studies have revealed that the cryopreservation of human semen increases sperm DNA fragmentation, the mechanisms involved in this type of cryo-injury are largely unknown. Elucidation of these mechanisms may provide insight into preventing such injury. METHODS: We obtained 60 semen samples from 60 men and conducted experiments to determine the cause of cryopreservation-induced DNA fragmentation...

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PMID: 19525298
DOI: 10.1093/humrep/dep214

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