High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin<i>in vivo</i>but is associated with transient adverse effects

Abstract excerpt

BACKGROUND: Evidence for beneficial effects of squalene on ultraviolet (UV)-induced photoageing of the skin is lacking. AIM: To investigate whether squalene supplementation improves signs and molecular markers of photoageing in human skin in vivo. METHODS: In total, 40 female volunteers aged > 50 years received two different doses [13.5 g/day (low-dose group) and 27 g/day (high-dose group)] of squalene for 90...

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