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Article

Spontaneous mutations in ageing human cells: studies using a Herpesvirus probe.

Mechanisms of ageing and development - 1 Jan 2000

Fulder S J

Abstract excerpt

Several fundamental theories of ageing postulate that spontaneous mutations increase in somatic cells as they age. This has not until recently been directly tested in mammalian cells, because of the problem of estimating mutation rate in declining cell populations. One possible approach is to infect cells with lytic virus and measure the mutation frequency in virus made by the cellular machinery. Three...

Topics

Aging
Animals
Cells, Cultured
Cricetinae
Fibroblasts
Humans
Lung
Mutation
Simplexvirus
Temperature

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 195146
DOI: 10.1016/0047-6374(77)90028-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-195146-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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