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Article

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers.

Pharmacogenetics and genomics - 1 Jun 2009

Lötsch Jörn, von Hentig Nils, Freynhagen Rainer, Griessinger Norbert, Zimmermann Michael, Doehring Alexandra, Rohrbacher Maren, Sittl Reinhard, Geisslinger Gerd

Abstract excerpt

AIM: A finite number of variants in the OPRM1, COMT, MC1R, ABCB1 and CYP2D6 genes has been identified to significantly modulate the effects of opioids in controlled homogenous settings. We analyzed the imprint of these variants in opioid therapy in a highly variable cohort of pain patients treated in outpatient units to test whether genotyping may play a role in this clinical setting. METHODS: In a multicenter...

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Source

Identifiers

PMID: 19514130
DOI: 10.1097/fpc.0b013e32832b89da

Genes

ABCB1
OPRM1
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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