Article
Disrupted cell cycle control in cultured endometrial cells from patients with endometriosis harboring the progesterone receptor polymorphism PROGINS.
The American journal of pathology - 1 Jul 2009
D'Amora Paulo, Maciel Thiago Trovati, Tambellini Rodrigo, Mori Marcelo A, Pesquero João Bosco, Sato Helio, Girão Manoel João Batista Castello, Guerreiro da Silva Ismael Dale Cotrim, Schor Eduardo
Abstract excerpt
Presently, little is understood about how endometriosis is established or maintained, or how genetic factors can predispose women to the disease. Because of the crucial role that the progesterone receptor polymorphism PROGINS plays in predisposing women to the development of endometriosis, we hypothesized that this variant may influence critical steps during endometrial cell metabolism that are involved in the...
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