Article
[Gene polymorphisms in patients with Down's syndrome].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2009
Kuz'mina N S, Ushenkova L I, Shagirova Zh M, Sheĭkhaev G O, Mikhaĭlov V F, Kurbatova L A, Mazurik V K, Rubanovich A V, Zasukhina G D
Abstract excerpt
Polymorphisms of glutation-S-transferase (GSTM1, GSTT1 GSTP1) and methylentetrahydrofolate reductase (MTHFR) genes have been studied in DNA from blood lymphocytes of 18 patients with Down's syndrome and 61 controls. Frequencies of normal alleles of GST genotypes were lower in patients as compared to the controls. A DNA analysis of 11 patients and 17 controls revealed the presence of mutations in region 246-250 of...
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