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Article

Differential regulation of glycogenolysis by mutant protein phosphatase-1 glycogen-targeting subunits.

The Journal of biological chemistry - 17 Jul 2009

Danos Arpad M, Osmanovic Senad, Brady Matthew J

Abstract excerpt

PTG and G(L) are hepatic protein phosphatase-1 (PP1) glycogen-targeting subunits, which direct PP1 activity against glycogen synthase (GS) and/or phosphorylase (GP). The C-terminal 16 amino residues of G(L) comprise a high affinity binding site for GP that regulates bound PP1 activity against GS. In this study, a truncated G(L) construct lacking the GP-binding site (G(L)tr) and a chimeric PTG molecule containing...

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Identifiers

PMID: 19487702
DOI: 10.1074/jbc.M109.015073
PMCID: PMC2740580

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