Article
Histological characterization of Darier's disease in Tunisian families.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Oct 2009
Kassar S, Tounsi-Kettiti H, Charfeddine C, Zribi H, Bchetnia M, Jerbi E, Mokni M, Ben Osman A, Abdelhak S, Boubaker S
Abstract excerpt
BACKGROUND: Darier's disease (OMIM 124200) is an autosomal-dominant skin disorder characterized by warty papules and plaques in seborreheic areas, palmo-plantar pits and distinctive nail abnormalities. The disease has complete penetrance in adults and variable expressivity. It is caused by mutations in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca(2+) ATPase type 2 isoform (SERCA2). OBJECTIVE:...
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