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Article

Genetic factors in mother-to-child transmission of HCV infection.

Virology - 20 Jul 2009

Bevilacqua Elena, Fabris Annalisa, Floreano Paolo, Pembrey Lucy, Newell Marie-Louise, Tovo Pier-Angelo, Amoroso Antonio

Abstract excerpt

HCV infection transmission rate in infants born to HCV-positive mothers is about 5%. HIV co-infection and high maternal RNA viral load are associated with increased transmission. The only genetic factor previously evaluated is HLA. We investigated the role of genetic factors already associated in adults with HCV infection evolution (HLA-DRB1, MBL2, TNF-alpha, IFN-gamma and IL-10), or liver disease progression...

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Share to Hemochromatosis Protein
Share to Hepatitis C
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Infectious Disease Transmission, Vertical

Share to Mannose-Binding Lectin

Share to Pregnancy Complications, Infectious

Source

Identifiers

PMID: 19481774
DOI: 10.1016/j.virol.2009.05.007

Genes

HFE
MBL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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